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The,,,PubMed,,,Search,,,strategy.doi:10.1371/journal.pone.0127652.s002(DOC),,,Author,,,ContributionsConceived,,,and,,,designed,,,the,,,experiments:,,,JM,,,LL.,,,In,Wnt1-Cre;pMes-caBmprIa,mice,at,the,same,stage,,strong,and,wide,spread,expression,of,BmprIa,was,found,in,the,TMJ,forming,region,and,its,surrounding,tissues,including,Meckel's,cartilage,,indicating,successful,transgenic,expression,of,BmprIa,in,CNC,lineage,(Fig.,pmid:20952163,,,View,,,Article,,,PubMed/NCBI,,,Google,,,Scholar,,,5.,,,Stottmann,RW,,Choi,M,,Mishina,Y,,Meyers,EN,,Klingensmith,J,(2004),BMP,receptor,IA,is,required,in,mammalian,neural,crest,cells,for,development,of,the,cardiac,outflow,tract,and,ventricular,myocardium.,A,BMPRIA-Ihh,positive,regulatory,pathway,regulates,TMJ,development,It,has,been,well,established,that,BMP,and,Ihh,signaling,interact,to,regulate,chondrocyte,proliferation,and,hypertrophic,differentiation,[34],,[53][55].,

Meanwhile,,,,Ihh,,,,produced,,,in,,,the,,,condyle,,,,diffuses,,,into,,,the,,,interzone,,,to,,,regulate,,,disc,,,separation,,,and,,,to,,,maintain,,,the,,,expression,,,of,,,BMPRIA,,,that,,,in,,,turn,,,acts,,,in,,,a,,,cell,,,autonomous,,,manner,,,to,,,regulate,,,synovial,,,membrane,,,formation,,,and,,,to,,,trigger,,,apoptosis.,,,View,,Article,,PubMed/NCBI,,Google,,Scholar,,50.,,Author,,,ContributionsConceived,,,and,,,designed,,,the,,,experiments:,,,YC,,,SG,,,WW.,,,Augmented,BMPRIA,signaling,in,CNC,cells,leads,to,TMJ,agenesis.(A,,B),In,situ,hybridization,shows,expression,of,BmprIa,in,the,condylar,condensation,,the,future,glenoid,fossa,forming,site,,and,the,interzone,region,,but,not,in,Meckel's,cartilage,of,an,E13.5,wild,type,embryo,(A),,and,an,enhanced,BmprIa,expression,in,the,TMJ,forming,site,as,well,as,the,surrounding,tissues,including,Meckel's,cartilage,in,an,E13.5,Wnt1-Cre;pMes-cBmprIa,embryo,(B).,DiscussionCompared,,,to,,,synovial,,,joint,,,formation,,,in,,,the,,,appendicular,,,skeletons,,,,TMJ,,,development,,,and,,,the,,,underlying,,,molecular,,,mechanisms,,,are,,,relatively,,,under-studied.,,,[21],,did,,not,,find,,significant,,any,,differences,,in,,the,,MIO,,and,,incidence,,of,,reankylosis,,between,,the,,patients,,who,,underwent,,GA,,and,,those,,who,,received,,IA,,,and,,he,,concluded,,that,,the,,success,,of,,treatment,,depended,,on,,patient,,cooperation,,,active,,physiotherapy,,,and,,regular,,follow-up.,,The,primary,outcome:,reankylosis,Eight,studies,with,a,total,of,272,patients,reported,the,information,about,incidence,of,reankylosis,[911,,14,,1922].,Hu,TX,,Li,ZB,,Yu,YH,,Li,Z,,Zhao,JH,,Gong,YJ.,

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